Construction of the current YMCA building commenced in 1928 and concluded in 1933. The design was entrusted to Arthur Loomis Harmon, an American architect renowned for co-designing the Empire State Building. Harmon’s design for the YMCA is a harmonious blend of Byzantine, Romanesque, and Moorish architectural styles, reflecting the city’s multifaceted heritage. ​

The Jerusalem YMCA has historically served as a center for cultural, athletic, and social activities. It was the site of Jerusalem’s first indoor swimming pool and hosted various events that brought together individuals from different backgrounds, promoting a spirit of community and coexistence.

The building is replete with symbolic elements that underscore its commitment to interfaith harmony:​

• The three prominent arches at the main entrance are widely interpreted as representing the three monotheistic religions—Judaism, Christianity, and Islam—extending a welcoming gesture to all visitors into a shared and inclusive space.
• The central tower, standing at an impressive 152 feet and comprising 12 floors, is imbued with symbolism related to both Jewish and Christian traditions, representing the 12 tribes of Israel and the 12 apostles. Architecturally, the tower’s transformation from a square base (symbolizing earth in Byzantine thought) to an octagon using squinches, which then supports a dome (representing heaven), reflects Byzantine religious beliefs.
• In the garden leading up to the building, twelve cypress trees are planted, each signifying the 12 tribes of Israel, the 12 disciples of Jesus, and the 12 followers of Mohammed, further emphasizing the theme of interfaith connection. This motif of the number twelve is repeated within the building, with 12 windows illuminating the domes and 12 stone arches rising above the balconies in the auditorium and gymnasium.
• Three significant inscriptions are engraved on the building’s façade, each a foundational declaration of faith from the three religions: “The Lord our God the Lord is One,” in Hebrew; “I am the way,” in Aramaic; and “There is no God but God,” in Arabic. These inscriptions are strategically placed to foster a sense of dialogue and mutual recognition between the faiths.
• The forty columns that define the courtyard hold dual symbolism, representing both the Children of Israel’s 40 years of wandering in the desert and the 40 days of the temptation of Jesus. The capitals of these columns are uniquely embellished with intricate carvings depicting the flora, fauna, and people of the land, reflecting the natural world and its inhabitants. Unlike classical Greek or Roman capitals, these Byzantine-inspired capitals are more ornate and varied.
• Above the main entrance, a striking bas-relief depicts a six-winged seraph, an image inspired by the vision of the prophet Isaiah (Isaiah 6:2). This motif resonates with both Jewish and Christian iconography.
  • Inside the building, an interfaith chapel was thoughtfully designed to accommodate worshippers of all faiths. This neutral sacred space incorporates symbols from Judaism, Christianity, and Islam, reflecting the YMCA’s commitment to mutual respect and understanding.
• Architectural details throughout the building further illustrate the eclectic blend of styles. Horseshoe arches are a distinct nod to Moorish architecture. Lancet (pointed) arches and internal rib-vaulted passageways and vaulted ceilings are characteristic elements of Gothic design. Above some arches, the use of alternating shades of Jerusalem stone may be inspired by the Mamluk architectural technique known as ablaq. The overall symmetrical plan and elevation of the building reflect classical influences. The domes of the gymnasium and concert hall, reminiscent of the Hagia Sophia, feature windows around their circumference and utilize pendentives to transition from a square base to an octagon that supports the dome, showcasing Byzantine architectural principles.
• The vestibule at the main entrance features a replica in mosaic of the Madaba Map, a historical map of the region, underscoring Jerusalem’s central significance.